DMT, or N,N-DMT, is a powerful hallucinogenic compound that shares similarities with other psychedelics such as LSD and psilocybin. Known for its profound psychoactive effects, DMT has a rich history of use, often tied to spiritual and ceremonial practices. Its effects are typically intense and include:

• Euphoria
• A sensation of floating
• Vivid visual and auditory hallucinations
• Feelings of depersonalization or dissociation
• Enhanced tactile sensations
• Revelatory or transformative experiences
• Spiritual insights

Though DMT has not garnered as much widespread attention as other hallucinogens, it boasts a significant historical and cultural legacy. It is one of the most notable naturally occurring psychedelics and is found in various Amazonian plants, such as those used in Ayahuasca brews, as well as in trace amounts within the human body. This trace presence is linked to its role in normal metabolic processes, where it is derived from the amino acid tryptophan. Remarkably, DMT is distinctive among classic hallucinogens in that it does not lead to the development of tolerance to its effects.

The compound was first synthesized in 1921 by Canadian chemist Richard Manske. It gained prominence in 1956 when its psychoactive properties were identified as the active ingredient in Cohoba, leading to further exploration of its effects.